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<i>Euphorbia cooperi<_i> N. E. Br. ex A. Berger

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By Targets:	Akt (1) Apoptosis (3) Autophagy (1) Biochemical Assay Reagents (1) Endogenous Metabolite (1) ERK (1) HIV (2) MAGL (1) P-glycoprotein (3) Parasite (1) PKC (1) RSV (1) Src (1) VEGFR (1)
By Research Areas:	Cancer (12) Endocrinology (1) Infection (4) Inflammation/Immunology (5) Metabolic Disease (2) Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N5001

Euphorbia Factor L2	Apoptosis	Cancer
Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. Euphorbia factor L2 shows potent cytotoxicity and induces apoptosis via a mitochondrial pathway .

HY-N8121

Euphorbia factor L7a

Others Others

Euphorbia factor L7a, a diterpenoid compound, can be isolated from the seeds of Euphorbia lathyris .
HY-N8118

Euphorbia factor L7b

Others Others

Euphorbia factor L7b is an isolathyrolditerpene compound .
HY-N8119

Euphorbia factor L8

Others Others

Euphorbia factor L(8) is a diterpenoid from the seeds of Euphorbia lathyris .
HY-N10875

Euphebracteolatin B

Others Others

Euphebracteolatin B is a nature product that could be isolated from Euphorbia fischeriana .
HY-N1645

2,16-Kauranediol

Kaurane-2β,16-diol
Others Others

2,16-Kauranediol, a diterpene compound, is a natural product that can be isolated from the aerial part of Euphorbia hirta .

Euphorbia factor L7a	Others	Others
Euphorbia factor L7a, a diterpenoid compound, can be isolated from the seeds of Euphorbia lathyris .

Euphorbia factor L7b	Others	Others
Euphorbia factor L7b is an isolathyrolditerpene compound .

Euphorbia factor L8	Others	Others
Euphorbia factor L(8) is a diterpenoid from the seeds of Euphorbia lathyris .

Euphebracteolatin B	Others	Others
Euphebracteolatin B is a nature product that could be isolated from Euphorbia fischeriana .

2,16-Kauranediol Kaurane-2β,16-diol	Others	Others
2,16-Kauranediol, a diterpene compound, is a natural product that can be isolated from the aerial part of Euphorbia hirta .

HY-138142

Euphol acetate	Others	Metabolic Disease
Euphol acetate is a triterpene that can be isolated from Euphorbia broteri. Euphol acetate is an inhibitor of hepatic transport proteins organic anion-transporting polypeptide 1/3 (OATP1B1/3) .

HY-N0867

13-Oxyingenol-13-dodecanoate	HIV	Infection
13-Oxyingenol-13-dodecanoate is an ester that can be isolated from Euphorbia kansui. 13-Oxyingenol-13-dodecanoate has anti-HIV-1 activity with EC₅₀ value of 33.7 nM .

HY-N7464

Jolkinolide E	Others	Others
Jolkinolide E is a casbane diterpenoid from the roots of Euphorbia rapulum. Jolkinolide E shows weak selective activity against HepG2, MCF-7, and C6 cell lines .

HY-N10990

Ingol 7,8,12-triacetate 3-(4-methoxyphenyl)acetate	Others	Others
Ingol 7,8,12-triacetate 3-(4-methoxyphenyl)acetate is a highly functionalized ingol diterpene that can be isolated from Euphorbia officinarum latex .

HY-N2556

Tirucallol	Others	Inflammation/Immunology
Tirucallol, a tetracyclic triterpene, is isolated from Euphorbia lacteal latex. Tirucallol has topical anti-inflammatory effect. Tirucallol can suppress ear edema in the mouse model and inhibit nitrite production in lipopolysaccharide-stimulated macrophages .

HY-137242

Ingenol-3-palmitate	HIV	Infection
Ingenol-3-palmitate, an ingenane diterpenoid, is a nature product that could be isolated from the roots of Euphorbia ebracteolata. Ingenol-3-palmitate is a potent HIV-1 (HIV) inhibitor with an IC₅₀ value of 4.1 nM .

HY-N7332

Pepluanin A	P-glycoprotein	Cancer
Pepluanin A is a natural compound isolated from Euphorbia peplus L. Pepluanin A shows a very high activity for a jatrophane diterpene, outperforming Cyclosporin A by a factor of at least 2 in the inhibition of Pgp-mediated Daunomycin (HY-13062A) transport ^[1]

HY-N0866

20-Deoxyingenol 1 Publications Verification	Autophagy	Inflammation/Immunology
20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA) .

HY-W123056

Candelilla wax Euphorbia CERIFERA (CANDELILLA) WAX	Biochemical Assay Reagents	Others
Candelilla wax is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-N10839

Yuexiandajisu E

Others Cancer

Yuexiandajisu E is a diterpenoid that can be found in Euphorbia ebracteolata .
HY-N1704

24-Methylenecycloartanol acetate

Others Others

24-Methylenecycloartanol acetate is a triterpene that can be found in Euphorbia segetalis .
HY-N7893

Ebracteolata cpd B

Others Others

Ebracteolata cpd B is a natural phenol compound found in Euphorbia ebracteolata .
HY-125114

Jatrophane 4

Others Others

Jatrophane 4 is a secondary metabolite of Euphorbia peplus. Jatrophane 4 is a diterpene .
HY-N9207

Germanicol acetate

Others Others

Germanicol acetate can be extracted from Euphorbia heterophylla L. and has phytotoxic activity .
HY-N11060

(Rac)-Dehydrovomifoliol

PBI 344
Others Others

(Rac)-Dehydrovomifoliol (PBI 344) is a bisnorsesquiterpene compound that can be found in Euphorbia peplus .
HY-N3401

Lasiodiplodin

Others Cancer

Lasiodiplodin is a potent anti-leukemic macrolide can be isolated from Euphorbia splendens .
HY-133209

Fischeria A

Others Cancer

Fischeria A is a norditerpene lactone of a new carbon skeleton, can be isolated from Euphorbia fischeriana .
HY-N0562

5,15-Diacetyl-3-benzoyllathyrol

Euphorbia factor L3
Others Cancer

5,15-Diacetyl-3-benzoyllathyrol is one of the lathyrane diterpenoids, that has anti-cancer activity.
HY-N0868

20-O-Acetylingenol-3-angelate

Euphorbia factor Pe1
Others Others

20-O-Acetylingenol-3-angelate is a natural compound.
HY-N11025

Kansenone

Others Others

Kansenone, a euphane-type triterpene, can be isolated from a 60% EtOH extract of Euphorbia kansui .
HY-137037

Ingenol 20-palmitate

Others Cancer

Ingenol 20-palmitate (compound 2) is a diterpene that can be found in Euphorbia lath yris .
HY-N0732

Jolkinolide B

Apoptosis Cancer

Jolkinolide B, a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud, is known to induce apoptosis in cancer cells .

Yuexiandajisu E	Others	Cancer
Yuexiandajisu E is a diterpenoid that can be found in Euphorbia ebracteolata .

24-Methylenecycloartanol acetate	Others	Others
24-Methylenecycloartanol acetate is a triterpene that can be found in Euphorbia segetalis .

Ebracteolata cpd B	Others	Others
Ebracteolata cpd B is a natural phenol compound found in Euphorbia ebracteolata .

Jatrophane 4	Others	Others
Jatrophane 4 is a secondary metabolite of Euphorbia peplus. Jatrophane 4 is a diterpene .

Germanicol acetate	Others	Others
Germanicol acetate can be extracted from Euphorbia heterophylla L. and has phytotoxic activity .

(Rac)-Dehydrovomifoliol PBI 344	Others	Others
(Rac)-Dehydrovomifoliol (PBI 344) is a bisnorsesquiterpene compound that can be found in Euphorbia peplus .

Lasiodiplodin	Others	Cancer
Lasiodiplodin is a potent anti-leukemic macrolide can be isolated from Euphorbia splendens .

Fischeria A	Others	Cancer
Fischeria A is a norditerpene lactone of a new carbon skeleton, can be isolated from Euphorbia fischeriana .

5,15-Diacetyl-3-benzoyllathyrol Euphorbia factor L3	Others	Cancer
5,15-Diacetyl-3-benzoyllathyrol is one of the lathyrane diterpenoids, that has anti-cancer activity.

20-O-Acetylingenol-3-angelate Euphorbia factor Pe1	Others	Others
20-O-Acetylingenol-3-angelate is a natural compound.

Kansenone	Others	Others
Kansenone, a euphane-type triterpene, can be isolated from a 60% EtOH extract of Euphorbia kansui .

Ingenol 20-palmitate	Others	Cancer
Ingenol 20-palmitate (compound 2) is a diterpene that can be found in Euphorbia lath yris .

Jolkinolide B	Apoptosis	Cancer
Jolkinolide B, a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud, is known to induce apoptosis in cancer cells .

HY-N10075

Euphohelioscopin A	P-glycoprotein	Others
Euphohelioscopin A is a diterpenoid can be isolated from the Euphorbia helioscopia L. plant. Euphohelioscopin A weakly inhibits P-glycoprotein-mediated efflux of mitoxantrone .

HY-N0425

Epoxylathyrol	P-glycoprotein	Cancer
Epoxylathyrol, an epoxylathyrane derivative isolated from the Euphorbia boetica, is a P-glycoprotein (P-gp) inhibitor. Epoxylathyrol is a P-gp-mediated multidrug resistance (MDR) reverser .

HY-N1596

Ent-16α,17-dihydroxykauran-3-one Ent-3-oxokaurane-16α,17-diol	Others	Others
Ent-16α,17-dihydroxykauran-3-one is a diterpenoid, which can be isolated from the roots of Euphorbia ebracteolata .

HY-N12434

Euphorblin R EOF2	Others	Metabolic Disease
Euphorblin R (EOF2) is a rhamnyl diterpenoid isolated from Euphorbia resinifera. Euphorblin R may promote lysosomal biogenesis and has the potential to be used in the study of lysosome-related diseases.

HY-125648

Euphorbadienol alpha-Euphorbol	Parasite	Infection
Euphorbadienol (alpha-Euphorbol), a triterpenic compound, isolated from the latex of Euphorbia resinifera. The derivatives of Euphorbadienol can be used as elicitors of disease resistance, and has antileishmanial and antitrypanosomal activity .

HY-N3970

Gopherenediol	Others	Neurological Disease
Gopherenediol is a diterpenoid with putative antifeedant activity against Mammalian herbivores. Gopherenediol is the active compound in to form deterrent effect, protects gopherweed, Euphorbia lathyris (Euphorbiaceae) from feeding by Mammalian herbivores .

HY-N7267

31-Norlanostenol	Others	Endocrinology
31-Norlanostenol is a triterpenic compound isolated from the latex of Euphorbia officinarum. 31-Norlanostenol can act as efficient insect growth regulator on S. frugiperda and Tenebrio molitor .

HY-N11027

5-O-Benzoyl-20-deoxyingenol	Others	Others
5-O-Benzoyl-20-deoxyingenol is a diterpene that can be isolated from the roots of Euphorbia kansui. 5-O-Benzoyl-20-deoxyingenol inhibits cell proliferation .

HY-N9280

ent-11α-Hydroxyabieta-8(14),13(15)-dien-16,12α-olide	Others	Others
ent-11α-Hydroxyabieta-8(14),13(15)-dien-16,12α-olide (compound 12) is a natural bioactive diterpenoid found in the roots of Euphorbia fischeriana .

HY-N10046

ent-17-Hydroxykauran-3-one ent-Kaurane-3-oxo-17β-ol	Others	Others
ent-17-Hydroxykauran-3-one (ent-Kaurane-3-oxo-17β-ol; compound 7) is a kaurane-type diterpenoid that can be found in the roots of Euphorbia fischeriana .

HY-N3443

Jolkinol A	Others	Cancer
Jolkinol A is a natural product that can be found in Euphorbia pubescens. Jolkinol A inhibits cell growth with GI₅₀s of 95.3, 57.3, >100 µM for MCF-7, NCI-460, SF-268 cells, respectively .

HY-N1969

3,3'-Di-O-methylellagic acid 3,8-Di-O-methylellagic acid
3,3'-Di-O-methylellagic acid obtained from Euphorbia adenochlora selectively inhibits the formation of acid-fastness in mycobacteria without retardation of their growth. 3,3'-di-O-methylellagic acid as a hepatoprotective compound is apparently due to its antioxidative effect .

HY-W744699

Larixol (+)-Larixol	Src ERK Akt	Inflammation/Immunology
Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Larixol can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Larixol inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM), cathepsin G release (IC₅₀: 2.76 μM), and chemotaxis. Larixol improves neutrophil hyperactivation and reduces inflammation or tissue damage. A series of Larixol derivatives were found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

HY-B0719

Ingenol Mebutate 1 Publications Verification Ingenol 3-angelate; PEP005	PKC	Inflammation/Immunology Cancer
Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with K_is of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.

HY-119767

Jolkinolide A	VEGFR Apoptosis	Cancer
Jolkinolide A is a diterpenoid, can be extracted from the roots of Euphorbia fischeriana Steud. Jolkinolide A exhibits anti-tumor activity, by affecting on angiogenesis of tumor tissues. Jolkinolide A significantly inhibits the Akt-STAT3-mTOR signaling pathway and reduces the expression of VEGF in A549 cells .

HY-N2333

Resiniferatoxin (+)-Resiniferatoxin
Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period .

HY-N0313

Euphol	MAGL Endogenous Metabolite	Inflammation/Immunology
Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC₅₀=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain .

HY-N3824

ent-Atisane-3β,16α,17-triol	Others	Others
ent-Atisane-3β,16α,17-triol is a compound that can be isolated from the acetone extract of roots of Euphorbia sieboldiana. ent-Atisane-3β,16α,17-triol is a natural control product .

HY-N3811

ent-11β-Hydroxyatis-16-ene-3,14-dione	RSV	Infection
ent-11β-Hydroxyatis-16-ene-3,14-dione (compound 11) is a diterpenoid from the fresh roots of Euphorbia jolkinii. ent-11β-Hydroxyatis-16-ene-3,14-dione has anti-RSV activity .

HY-N7168A

3-O-(2'E ,4'Z-Decadienoyl)-20-O-acetylingenol	Others	Others
3-O-(2'E ,4'Z-Decadienoyl)-20-O-acetylingenol (compound 6) is a diterpene that can be isolated from Euphorbia kansui. 3-O-(2'E ,4'Z-Decadienoyl)-20-O-acetylingenol shows cleavage inhibition activity of individual Xenopus cells at the blastular stage .

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<i>Euphorbia cooperi<_i> N. E. Br. ex A. Berger

Inhibitors & Agonists

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